Dendritic complexity and formation of Circuits

Layer 2/3 of the cerebral cortex have specifically expanded in humans due to changes in their proliferation rates in the progenitors. Their dendritic arborization determines the information processing and behavioural outputs in the brain.

Publications

Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signaling pathway

Mahima Bose, Ishita Talwar, Varun Suresh, Urvi Mishra, Shiona Biswas, Anuradha Yadav, Shital T. Suryavanshi, Simon Hippenmeyer, Shubha Tole

Biorxiv, 2024

LHX2 regulates dendritic morphogenesis in layer II/III of the neocortex via distinct pathways in progenitors and postmitotic neurons.

Mahima Bose, Sanjna Kumari Sreenath Ravindran, Achintya Srivastava, Archana Iyer, Binita Vedak, Ishita Talwar, Rishikesh Narayanan, Shubha Tole

Biorxiv, 2024 Jun

PRDM16 co-operates with LHX2 to shape the human brain

Varun Suresh, B. Bhattacharya, Rami Yair Tshuva, Miri Danan Gotthold, T. Olender, Mahima Bose, S. Pradhan, B. Ben Zeev, R. S. Smith, S. Tole, S. Galande, Corey C. Harwell, José-Manuel Baizabal, O. Reiner

bioRxiv, 2023

Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2.

Varun Suresh, Bhavana Muralidharan, S. Pradhan, Mahima Bose, Leora D’Souza, Arpan Parichha, P. C. Reddy, S. Galande, S. Tole

PLoS Genetics, 2023